Sunday, April 7, 2013

My DNA Results Are Out! / Genographic Project 2.0

The Geno 2.0 project must be the most interesting crowd sourcing science project that National Geographic has ever done. I did the Geno 1.0 test 5 years ago. Last year they improved the technology and launched Geno 2.0.  I ordered online on 13th January and received the results on 6th April; around 3 months turnaround.

The story goes like this: our DNA is like a huge history book which tells the story of how our ancestors travelled from Africa and populated all areas around the world. The heart of the matter is that we were all Africans, and we are all family (not just in the metaphorical sense but factually), descended from just a few humans many tens of thousands of years ago. The fact that we are able to know this, in this century that we happen to be in, is nothing short of breathtaking.
 

The newer Geno test includes new information that can only get more interesting as more people contribute their background information to add to the data pool. The following are the results I have received. All pictures can be enlarged.

Your story
Your chapter of the human story is ready to be told. The results of your Genographic Project test reveal information about your distant ancestors, including how and when they moved out of Africa and the various populations they interacted with over thousands of years of migration. How do we do this? By tracking markers—random, naturally occurring, changes in your DNA. The mutations act as a beacon and can be mapped over thousands of years (on the Y-chromosome for paternal lines and mitochondrial DNA for maternal lines). When geneticists identify such a marker, they try to figure out when it first occurred, and in which geographic region of the world. In the report below, you will see the group with which you share genetic markers on your paternal and/or maternal sides. This is called your “haplogroup,” and is expressed in numbers and letters.

Introduction to Your Story
We will now take you back through the stories of your distant ancestors and show how the movements of their descendants gave rise to your lineage.

Each segment on the map above represents the migratory path of successive groups that eventually coalesced to form your branch of the tree. We start with the marker for your oldest ancestor, and walk forward to more recent times, showing at each step the line of your ancestors who lived up to that point.

What is a marker? Each of us carries DNA that is a combination of genes passed from both our mother and father, giving us traits that range from eye color and height to athleticism and disease susceptibility. As part of this process, the Y-chromosome is passed directly from father to son, unchanged, from generation to generation down a purely male line. Mitochondrial DNA, on the other hand, is passed from mothers to their children, but only their daughters pass it on to the next generation. It traces a purely maternal line.

The DNA is passed on unchanged, unless a mutation—a random, naturally occurring, usually harmless change—occurs. The mutation, known as a marker, acts as a beacon; it can be mapped through generations because it will be passed down for thousands of years.

When geneticists identify such a marker, they try to figure out when it first occurred, and in which geographic region of the world. Each marker is essentially the beginning of a new lineage on the family tree of the human race. Tracking the lineages provides a picture of how small tribes of modern humans in Africa tens of thousands of years ago diversified and spread to populate the world.

By looking at the markers you carry, we can trace your lineage, ancestor by ancestor, to reveal the path they traveled as they moved out of Africa. Our story begins with your earliest ancestor. Who were they, where did they live, and what is their story? 


Your Maternal Line: B4c1b2a
The common direct maternal ancestor to all women alive today was born in East Africa about 180,000 years ago. Though not the only woman alive at the time, hers is the only line to survive into current generations.

From East Africa, groups containing this lineage spread across Africa. Between 60 and 70 thousand years ago, some groups moved from Africa to Asia. Your line traces to one of these groups.

Some from your line spread across Asia and settled. Others traveled across the Beringia land bridge to the Americas.

 
Branch: L3
Age: 70,000 Years Ago
Location of Origin: East Africa
 

This woman’s descendants would eventually account for both out-of-Africa maternal lineages, significant population migrations in Africa, and even take part in the Atlantic Slave Trade related dispersals from Africa.

The common direct maternal ancestor to all women alive today was born in East Africa around 180,000 years ago. Dubbed “Mitochondrial Eve” by the popular press, she represents the root of the human family tree. Eve gave rise to two descendant lineages known as L0 and L1’2’3’4’5’6, characterized by a different set of genetic mutations their members carry.

Current genetic data indicates that indigenous people belonging to these groups are found exclusively in Africa. This means that, because all humans have a common female ancestor, and because the genetic data shows that Africans are the oldest groups on the planet, we know our species originated there.

Eventually, L1’2’3’4’5’6 gave rise to L3 in East Africa. It is a similar story: an individual underwent a mutation to her mitochondrial DNA, which was passed onto her children. The children were successful, and their descendants ultimately broke away from L1’2’3’4’5’6, eventually separating into a new group called L3.

While L3 individuals are found all over Africa, L3 is important for its movements north. Your L3 ancestors were significant because they are the first modern humans to have left Africa, representing the deepest branches of the tree found outside of that continent.

From there, members of this group went in a few different directions. Many stayed on in Africa, dispersing to the west and south.  Some L3 lineages are predominant in many Bantu-speaking groups who originated in west-central Africa, later dispersing throughout the continent and spreading this L3 lineage from Mali to South Africa.  Today, L3 is also found in many African-Americans.

Other L3 individuals, your ancestors, kept moving northward, eventually leaving the African continent completely. These people gave rise to two important haplogroups that went on to populate the rest of the world.

Why would humans have first ventured out of the familiar African hunting grounds and into unexplored lands? It is likely that a fluctuation in climate may have provided the impetus for your ancestors’ exodus out of Africa.

The African Ice Age was characterized by drought rather than by cold. Around 50,000 years ago the ice sheets of northern Europe began to melt, introducing a period of warmer temperatures and moister climate in Africa. Parts of the inhospitable Sahara briefly became habitable. As the drought-ridden desert changed to savanna, the animals your ancestors hunted expanded their range and began moving through the newly emerging green corridor of grasslands. Your nomadic ancestors followed the good weather and plentiful game northward across this Saharan Gateway, although the exact route they followed remains to be determined.

Point of Interest: The L branch is shared by all women alive today, both in Africa and around the world.


Branch: N
Age: About 60,000 Years Ago
Location of Origin: East Africa or Asia
 


Your next ancestor is the woman whose descendants formed haplogroup N. Haplogroup N comprises one of two groups that were created by the descendants of L3.

One of these two groups of individuals moved north rather than east and left the African continent across the Sinai Peninsula, in present-day Egypt. Also faced with the harsh desert conditions of the Sahara, these people likely followed the Nile basin, which would have proved a reliable water and food supply in spite of the surrounding desert and its frequent sandstorms.

Descendants of these migrants eventually formed haplogroup N. Early members of this group lived in the eastern Mediterranean region and western Asia, where they likely coexisted for a time with other hominids such as Neanderthals. Excavations in Israel’s Kebara Cave (Mount Carmel) have unearthed Neanderthal skeletons as recent as 60,000 years old, indicating that there was both geographic and temporal overlap of these two hominids.  This likely accounts for the presence of Neanderthal DNA in people living outside of Africa.

Some members bearing mutations specific to haplogroup N formed many groups of their own which went on to populate much of the rest of the globe. These descendants are found throughout Asia, Europe, India, and the Americas. However, because almost all of the mitochondrial lineages found in the Near East and Europe descend from N, it is considered a western Eurasian haplogroup.

After several thousand years in the Near East, members of your group began moving into unexplored nearby territories, following large herds of migrating game across vast plains. These groups broke into several directions and made their way into territories surrounding the Near East.

Today, haplogroup N individuals who headed west are prevalent in Turkey and the eastern Mediterranean, they are found further east in parts of Central Asia and the Indus Valley of Pakistan and India. And members of your haplogroup who headed north out of the Levant across the Caucasus Mountains have remained in southeastern Europe and the Balkans. Importantly, descendants of these people eventually went on to populate the rest of Europe, and today comprise the most frequent mitochondrial lineages found there. 


Branch: R
Age: About 55,000 Years Ago
Location of Origin: West Asia


After several thousand years in the Near East, individuals belonging to a new group called haplogroup R began to move out and explore the surrounding areas. Some moved south, migrating back into northern Africa. Others went west across Anatolia (present-day Turkey) and north across the Caucasus Mountains of Georgia and southern Russia. Still others headed east into the Middle East, and on to Central Asia. All of these individuals had one thing in common: they shared a female ancestor from the N clan, a recent descendant of the migration out of Africa.

The story of haplogroup R is complicated, however, because these individuals can be found almost everywhere, and because their origin is quite ancient. In fact, the ancestor of haplogroup R lived relatively soon after humans moved out of Africa during the second wave, and her descendants undertook many of the same migrations as her own group, N.

Because the two groups lived side by side for thousands of years, it is likely that the migrations radiating out from the Near East comprised individuals from both of these groups. They simply moved together, bringing their N and R lineages to the same places around the same times. The tapestry of genetic lines became quickly entangled, and geneticists are currently working to unravel the different stories of haplogroups N and R, since they are found in many of the same far-reaching places.

Point of Interest: Descendants of this line dominate the European maternal landscape, making up 75 to 95 percent of the lineages there.


Branch: B4'5
Age: About 51,000 Years Ago
Location of Origin: Asia


Born in the deserts and plains between the Caspian Sea and Lake Baikal in Central Asia, some of this woman’s descendants migrated into East Asia. There it became a founding lineage. Around 17,000 years ago, a population explosion in East Asia triggered expansion into new lands. From northeastern Asia, groups that included this lineage traveled south along the Pacific coast, and this lineage is now part of populations from Vietnam to Japan. During the last glacial maximum, about 15,000 years ago, a corridor opened between Siberia and North America.

Some members of a descendant branch moved across into the Americas. This branch was one of only five founding lineages, and today is part of the populations throughout native groups of North and South America.

Today, this lineage is around 3 percent of Siberians and around 17 percent of all Chinese people. European colonization and loss of native lands to urbanization has diminished its presence in the indigenous populations of the Americas. However, it remains significant in remaining populations.

Branch: B4
Age: 44,200 ± 11,600 Years Ago
Location of Origin: Asia


Members of this maternal lineage spread across much of Asia and some descendants became early founders in the Americas.

Note: This branch is not accompanied by a major movement on the map, and research on this branch is continuing.

Branch: B4c1b
Age: To Be Determined
Location of Origin: Asia


While some groups containing women from this lineage traveled up the Indus Valley and across into Central Asia, others moved along the coastline toward East Asia and Southeast Asia.

Note: This branch is not accompanied by a major movement on the map, and research on this branch is continuing.


  
Heatmap for B4 
A heat map for your specific haplogroup is not yet available. We hope that as more people from around the world participate in the project we will be able to create a more specific map. We're showing you a heat map for an earlier branch in your path: B4.

This next step in your journey is a map showing the frequency of your haplogroup (or the closest haplogroup in your path that we have frequency information for) in indigenous populations from around the world, providing a more detailed look at where some of your more recent ancestors settled in their migratory journey. What do we mean by recent? It's difficult to say, as it could vary from a few hundred years ago to a few thousand years ago depending on how much scientists currently know about your particular haplogroup. As we test more individuals and receive more information worldwide, this information will grow and change.

The colors on the map represent the percentage frequency of your haplogroup in populations from different geographic regions—red indicates high concentrations and light yellow and grey indicate low concentrations. The geographic region with the highest frequency isn’t necessarily the place where the haplogroup originated, although this is sometimes the case.

The map of B4 shows that it spread across in Eastern Eurasia and to the Americas. This spread is due to the lineage’s expansion from Asia into North America. The highest frequencies in East Asia are along the coastline and down into Oceana. In the Americas, the frequencies show migrations across the plains of North America and along the western coast of South America.

Does this mean you’re related to people in the areas highlighted on your map? Distantly, yes! We are all connected through our ancient ancestry. In order for us to learn more ancestry information about where haplogroups settled in more recent times, please choose to contribute your results to science (check the checkbox during Login or from the Account Settings tab of your Profile), and fill out your ancestry information in the Profile section of the site. Also be sure to tell your own story in the Our Story section.


****************

Your Paternal Line: O-L198 
The common direct paternal ancestor of all men alive today was born in Africa around 140,000 years ago. He was neither the first human male nor the only male alive in his time. He was the only male whose direct lineage is present in current generations. Most men, including your direct paternal ancestors, trace their ancestry to one of this man’s descendants.

Your branch of this lineage took part in the second wave of out-of-Africa migrations to Asia. Your ancestors traveled to Southeast Asia. Some continued north into East Asia. The majority of these men traveled inland across what is now the south of China. From inland China, some traveled back toward the west into the northeast of the Indian subcontinent.

Branch: M42
Age: About 75,000 Years Ago
Location of Origin: Africa


The common direct paternal ancestor of all men alive today was born in Africa around 140,000 years ago. Dubbed “Y-chromosome Adam” by the popular press, he was neither the first human male nor the only man alive in his time. He was, though, the only male whose Y-chromosome lineage is still around today.  All men, including your direct paternal ancestors, trace their ancestry to one of this man’s descendants. The oldest Y-chromosome lineages in existence, belonging to the A branch of the tree, are found only in African populations.

Around 75,000 years ago, the BT branch of the Y-chromosome tree was born, defined by many genetic markers, including M42. The common ancestor of most men living today, some of this man’s descendants would begin the journey out of Africa, to India and the Middle East. Small groups would eventually reach the Americas. Others would settle in Europe, and some from this line remained near their ancestral homeland in Africa.

Individuals from this line in Africa often practice cultural traditions that resemble those of their distant ancestors. For example, they often live in traditional hunter-gatherer societies. These include the Mbuti and Biaka Pygmies of central Africa, as well as Tanzania’s Hadza.

As M42-bearing populations migrated around the globe, they picked up additional markers on their Y-chromosomes. Today, there are no known BT individuals without these additional markers.

Point of Interest: The M42 branch is shared by almost all men alive today, both in Africa and around the world.



Branch: M168
Age: About 70,000 years ago
Location of Origin: Africa/Asia


As humans left Africa, they migrated across the globe in a web of paths that spread out like the branches of a tree, each limb of migration identifiable by a marker in our DNA. For male lineages, the M168 branch was one of the first to leave the African homeland.

Moving outward from Africa and along the coastline, members of this lineage were some of the earliest settlers in Asia, Southeast Asia, and Australia. Some from this line would even travel over the land bridge to reach the Americas.

The man who gave rise to the first genetic marker in your lineage probably lived in northeast Africa in the region of the Rift Valley, perhaps in present-day Ethiopia, Kenya, or Tanzania.  Scientists put the most likely date for when he lived at around 70,000 years ago. His descendants became the only lineage to survive outside of Africa, making him the common ancestor of every non-African man living today.

But why would man have first ventured out of the familiar African hunting grounds and into unexplored lands? The first migrants likely ventured across the Bab-al Mandeb strait, a narrow body of water at the southern end of the Red Sea, crossing into the Arabian Peninsula soon after M168 originated—perhaps 65,000 years ago. These beachcombers would make their way rapidly to India and Southeast Asia, following the coastline in a gradual march eastward.  By 50,000 years ago, they had reached Australia. These were the ancestors of today’s Australian Aborigines.

It is also likely that a fluctuation in climate may have contributed to your ancestors’ exodus out of Africa. The African ice age was characterized by drought rather than by cold. Around 50,000 years ago, though, the ice sheets of the northern hemisphere began to melt, introducing a short period of warmer temperatures and moister climate in Africa and the Middle East. Parts of the inhospitable Sahara briefly became habitable. As the drought-ridden desert changed to a savanna, the animals hunted by your ancestors expanded their range and began moving through the newly emerging green corridor of grasslands.

Your nomadic ancestors followed the good weather and the animals they hunted, although the exact route they followed remains to be determined. In addition to a favorable change in climate, around this same time there was a great leap forward in modern humans’ intellectual capacity. Many scientists believe that the emergence of language gave us a huge advantage over other early human species. Improved tools and weapons, the ability to plan ahead and cooperate with one another, and an increased capacity to exploit resources in ways we hadn’t been able to earlier, all allowed modern humans to rapidly migrate to new territories, exploit new resources, and replace other hominids such as the Neanderthals.

Point of Interest: This male branch is one of the first to leave the African homeland.



Branch: M89
Age: Around 50,000 Years Ago
Location of Origin: South Asia or West Asia


The next male ancestor in your ancestral lineage is the man who gave rise to M89, a marker found in 90 to 95 percent of all non-Africans. This man was born around 50,000 years ago in northern Africa or the Middle East.

The first people to leave Africa likely followed a coastal route that eventually ended in Australia. Your ancestors followed the expanding grasslands and plentiful game to the Middle East and beyond, and were part of the second great wave of migration out of Africa.

Beginning about 40,000 years ago, the climate shifted once again and became colder and more arid. Drought hit Africa and the grasslands reverted to desert, and for the next 20,000 years, the Saharan Gateway was effectively closed. With the desert impassable, your ancestors had two options: remain in the Middle East, or move on. Retreat back to the home continent was not an option.

While many of the descendants of M89 remained in the Middle East, others continued to follow the great herds of wild game through what is now modern-day Iran to the vast steppes of Central Asia.

These semi-arid grass-covered plains formed an ancient “superhighway” stretching from eastern France to Korea. Your ancestors, having migrated north out of Africa into the Middle East, then traveled both east and west along this Central Asian superhighway. A smaller group continued moving north from the Middle East to Anatolia and the Balkans, trading familiar grasslands for forests and high country.

Today, geneticists have found the lineage in 1 to 2 percent of Pakistani and Indian populations. However, it is about 4 percent of some Austro-Asiatic-language-family-speaking groups in India. It is about 9 percent of some Dravidian-language-family-speaking groups in India, and it is 9 to 10 percent of male lineages in Sri Lanka. In Borneo, it is about 5 percent of the population. In Malaysia, it is about 6 percent of the population. 




Branch: P128
Age: About 45,000 years ago
Location of Origin: South Asia


The next male ancestor in your ancestral lineage is the man who gave rise to P128, a marker found in more than half of all non-Africans alive today. This man was born around 45,000 years ago in the Middle East or Central Asia.

The descendants of P128 migrated to the east and north, picking up additional markers on their Y-chromosomes. This lineage is the parent of several major branches on the Y-chromosome tree: O, the most common lineage in East Asia; R, the major European Y-chromosome lineage; and Q, the major Y-chromosome lineage in the Americas. These descendant branches went on to settle the rest of Asia, the Americas, and Europe; many others traveled to Southeast Asia.

Today, P128 individuals lacking these additional markers are rare in most populations, and are most commonly seen in Oceanian and Australian Aboriginal populations.



Branch: M214
Age: About 35,000 years ago
Location of Origin: Central Asia


This branch marks another major turning point in your ancestors’ journey. The founder of this lineage was a nomad in the time of the Paleolithic.

His descendants founded two major descendant branches. One would travel north and settle East Asia through Siberia. Some from this line would eventually turn back west and travel to Scandinavia. The second of the two branches would travel another road across South Asia. It too would eventually reach East Asia.



Branch: P186
Age: 28,000 – 41,000 Years Ago
Location of Origin: Southeast Asia


Groups containing this lineage traveled along the coastline of Asia into Southeast Asia. From there, some from this lineage continued north into East Asia. The majority of these men traveled inland across what is now the south of China. Thus, this came to be the highest frequency lineage in the region. From inland China, some traveled back toward the west into the northeast of the Indian subcontinent.

Today, geneticists have found this lineage at varying frequencies in South Asian populations. It is about 23 percent of the overall Indian male population. However, in the northeast the frequency reaches about 80 percent. In Japan, its frequency is between 47 and 65 percent. In Korea, it is between 70 and 82 percent of the male population. It is between 69 and 86 percent of male lineages in Han population groups.



Branch: M268
Age: About 30,000 Years Ago
Location of Origin: Asia


Men from this lineage traveled along the coast of Asia toward Southeast Asia and settled the shorelines followed by the outlying islands.

Today, it is most common in Korea (32 percent), the islands of Japan (38 percent), and among the Yao in China (20 percent).




Heatmap for M268
This next step in your journey is a map showing the frequency of your haplogroup (or the closest haplogroup in your path that we have frequency information for) in indigenous populations from around the world, providing a more detailed look at where some of your more recent ancestors settled in their migratory journey. What do we mean by recent? It's difficult to say, as it could vary from a few hundred years ago to a few thousand years ago, depending on how much scientists currently know about your particular haplogroup. As we test more individuals and receive more information worldwide, this information will grow and change.

The colors on the map represent the varying percentage frequencies of your haplogroup in populations from different geographic regions—red indicates high concentrations, and light yellow and grey indicate low concentrations. The geographic region with the highest frequency isn’t necessarily the place where the haplogroup originated, although this is sometimes the case.

You may find that your map shows a wide distribution for your haplogroup, with large portions of the world highlighted, or unusual places far from where you live. Does this mean you’re related to people in all of those places? Distantly, yes! We are all connected through our ancient ancestry.

In order for us to learn more ancestry information about where haplogroups settled in more recent times, please choose to contribute your results to science (check the checkbox during Login or from the Account Settings tab of your Profile), and fill out your ancestry information in the Profile section of the site. Also be sure to tell your own story in the Our Story section.




****************



Who am I?
We are all more than the sum of our parts, but the results below offer some of the most dramatic and fascinating information in your Geno 2.0 test. In this section, we display your affiliations with a set of nine world regions. This information is determined from your entire genome so we’re able to see both parents’ information, going back six generations. Your percentages reflect both recent influences and ancient genetic patterns in your DNA due to migrations as groups from different regions mixed over thousands of years. Your ancestors also mixed with ancient, now extinct hominid cousins like Neanderthals in Europe and the Middle East or the Denisovans in Asia. If you have a very mixed background, the pattern can get complicated quickly! Use the reference population matches below to help understand your particular result.


What Your Results Mean
Modern day indigenous populations around the world carry particular blends of these regions. We compared your DNA results to the reference populations we currently have in our database and estimated which of these were most similar to you in terms of the genetic markers you carry. This doesn’t necessarily mean that you belong to these groups or are directly from these regions, but that these groups were a similar genetic match and can be used as a guide to help determine why you have a certain result. Remember, this is a mixture of both recent (past six generations) and ancient patterns established over thousands of years, so you may see surprising regional percentages. Read each of the population descriptions below to better interpret your particular result.


 

Your first reference population: Japanese 
This reference population is based on samples collected from the Japanese population. The 75% Northeast Asian and 25% Southeast Asian percentages are representative of migrations in East Asia, with the Northeast Asian component likely coming from the earliest settlers in eastern Siberia and northern China. The Southeast Asian component reflects mixing with groups that originated further south.


Your second reference population: Kinh (Vietnam)

This reference population is based on samples collected from the Kinh ethnic group living in Vietnam, the largest ethnic group in the country.  The 57% Northeast Asian and 43% Southeast Asian percentages are representative of migrations in East Asia, with the Northeast Asian component likely coming from the earliest settlers in eastern Siberia and northern China. The Southeast Asian component reflects mixing with groups that originated further south.


Edit: I'm not sure why I'm not Chinese. I seem to be closer to this group based on the following reference population.

This reference population is based on samples collected from the population of Beijing, China. The 72% Northeast Asian and 28% Southeast Asian percentages are representative of migrations in East Asia, with the northeast Asian component likely coming from the earliest settlers in eastern Siberia and northern China, and the southeast Asian component reflecting mixing with groups that originated further south.


Your hominid ancestry
When our ancestors first migrated out of Africa around 60,000 years ago, they were not alone. At that time, at least two other species of hominid cousins walked the Eurasian landmass: Neanderthals and Denisovans. Most non-Africans are about 2% Neanderthal. The Denisovan component of your Geno 2.0 results is more experimental, as we are still working to determine the best way to assess the percentage Denisovan ancestry you carry. The evolution of this data is another way you are actively involved in helping advance knowledge of anthropological genetics!

More info: https://genographic.nationalgeographic.com/overview-of-regions-and-closest-populations/



****************

Our story
The story of the Genographic Project is one shared by every participant. It is only through the collection of hundreds of thousands of samples from people around the world that scientists have been able to determine the migratory paths taken by our ancient ancestors. In this section, you will see other Geno 2.0 participants who share your genetic markers on your paternal and/or maternal side, and find out what they know about their more recent family history. Participants are displayed on the circle below with those most closely related near you in the center of the circle, and those more distantly related on the outside (time ranges vary by group).